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Mind and body are interdependent, if the mind is disturbed, the effect of it will be seen physically. Stress and strain affects all the body systems and also the root of all systems i.e immune system. So, mind responsibility to protect one’s body from all kinds of ailments. Well-being is a state of mind. It is a contented state of being happy and healthy and prosperous. Wellness encourages activities that lead to well-being. Physical wellness is about how our dietary habits and food choices are influencing our well-being. The systematic and regular practice of yoga to regulate the relation between body and mind, strengthening body and mind, improves immunity, which help in building up a sound physical and mental health of yoga practitioners. In the sense the practice of yoga improves energy and positive well-being and decreases anxiety and depression.The objective of present study is to examine the influence of yoga practice on well-being of yoga practitioners. The findings of the study indicated that the well-being of the yoga practitioners are influenced by their marital, employment, duration of yoga practice and health status. For instance, unmarried yoga practitioners report significantly higher levels of anxiety and depression. Yoga practitioners who are not employed report significantly more depression and anxiety and lesser energy than those who are employed. Yoga practitioners who have no health problems report significantly lesser depression and anxiety and enhanced energy and positive well-being. Further, older practitioners report lesser depression and anxiety and increase in the duration of yoga practice has all round benefits for well-being as it results in reduced depression and anxiety and increased energy and positive well-being.