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The research was conducted to understand the considering nursing's mediation impact working environment in the effect of nurses' perception about improved sufferer nurse practices in smaller or middle hospitals. The data for this study were collected from 192 registered nurses with more than 6 months or experience working in four smaller or middle clinics inside the metro region of U from August 17, 2020 to August 31, 2020. The data analysis of this study was performed using IBM SPSS ver.21.0 program. Mean, the average deviation, percentage t-test or Multiple Linear regression, Pearson's Coefficient, or Correlation, ANOVA, Scheffé test, or Sobel test were used as data analysis methods to achieve the purpose of this study. As a result, patient safety nursing activity and the attitude of medication satisfaction were shown to be significantly positively correlated. Awareness and the setting for professional nursing and this were discovered that the clinical workplace partially mediates the relationship mindset of medication satisfaction perception and patient safety nursing activity.